IL-1 receptor

Examples: IL-1 receptor types.

They have a natural antagonist IL-1Ra (IL-1 receptor antagonist).

Crystal structure analysis of the mature form of IL-1α shows that it has two sites of binding to IL-1 receptor.

Intrathecal injection of antiserum against dynorphin A (1-17) and IL-1 receptor antagonist significantly inhibited the cancer-induced hyperalgesia.

DIRA (deficiency of the IL-1 receptor antagonist)

They highly up-regulate expression of IL-1 receptor and RORγt on the surface of stimulated Th17 lymphocytes.

The signaling can be triggered by a precursor form of IL-33 in the same way as IL-1α precursor activates signaling through IL-1 receptor.

Immunex researchers hope to use their genetically engineered copy of the IL-1 receptor as a free-floating decoy that attaches to IL-1 before it reaches its target cells.

All three of them bind IL-1 receptor (IL-1R) and activate signaling via MyD88 adaptor, which is described in part Signaling of this page.

The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.

IL-1 receptor antagonist and IL-1β treatment Human IL-1Ra or IL-1β was delivered as a recombinant protein or by expression of its cDNA from genetically modified cells.

This recruits 'Il-1 Receptor Associated Kinase' (IRAK) and 'Tumour necrosis factor Receptor Associated Factors' (TRAFs).

The receptors both exist in transmembrane (TM) and soluble forms: the soluble IL-1 receptor is thought to be post-translationally derived from cleavage of the extracellular portion of the membrane receptors.

In patients with rheumatoid arthritis the natural IL-1 receptor antagonist is not found in effective concentrations in synovium and synovial fluid to counteract the elevated IL-1 concentrations in these patients.

So, there was an effort to block IL-1 activity by natural IL-1 receptor antagonist (IL-1Ra), also familiar by its generic name anakinra, but in the end the control trials did not reached statistical significance.

Research indicates that mice with a genetic deletion of the IL-1 receptor type I display markedly impaired hippocampal-dependent memory functioning and Long-term potentiation, although memories that do not depend on the integrity of the hippocampus seem to be spared.

Two types of IL-1 receptor, each with three extracellular immunoglobulin (Ig)-like domains, limited sequence similarity (28%) and different pharmacological characteristics have been cloned from mouse and human cell lines: these have been termed type I and type II receptors.