HMG proteins

HMG proteins are thought to play a significant role in various human disorders.

HMG proteins function as architectural factors and are essential components of the enhanceosome.

Antibodies to HMG proteins are found in patients suffering from autoimmune diseases.

The HMG proteins are subdivided into 3 superfamilies each containing a characteristic functional domain:

Disruptions and rearrangements in the genes coding for some of the HMG proteins are associated with some common benign tumors.

HMG proteins contain DNA-binding domains that allow them to produce specific changes in target DNA structure [ 2 3 ] .