HIV-1 protease

On the one hand, lipodystrophy seems to be mainly due to HIV-1 protease inhibitors.

Tipranavir is a nonpeptidic HIV-1 protease inhibitor and reached the market in 2005.

Examples include HIV-1 protease, racemases, β-lactamases, metalloproteinases, cyclooxygenases and many others.

HIV is dependent on an enzyme called the HIV-1 protease for the virus to become infectious.

Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease.

These pigments were selected due to a similar in shape to the successful HIV-1 protease inhibitor Merck L-700,417.

The HIV-1 protease is an enzyme that cleaves a very large HIV protein into smaller, functional proteins.

HIV-1 protease is one of the best known aspartic proteases, and an attractive target for the treatment of AIDS.

Influence of the protease flap movement on calculated binding energy The beta-strand flap is the most flexible region in the HIV-1 protease.

Protein protonation states were modeled as in the related HIV-1 protease MD simulation study [ 56 ] .

Life-threatening interactions between HIV-1 protease inhibitors and the illicit drugs MDMA and gamma-hydroxybutyrate.

The observation that HIV-1 protease cleaves the sequences containing the dipeptides Tyr-Pro or Phe-Pro was the basic design criterion.

FightAIDS@Home makes use of the AutoDock software, which tests how well a particular molecule binds to the HIV-1 protease.

A 1996 study by McPhee et al. suggested that biliverdin - as well as many other tetrapyrrolic pigments - may function as an HIV-1 protease inhibitor.

Specifically, drugs in this class disrupt the final step in the processing of the HIV-1 gag protein, the cleavage of its immediate precursor by the enzyme HIV-1 protease.

HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV, the retrovirus that causes AIDS.

In particular, C inhibits a key enzyme in the human immunodeficiency virus known as HIV-1 protease; this could inhibit reproduction of the HIV virus in immune cells.

It is clear that relaxation of HIV-1 protease for 0.1 ps MD simulations is enough for rearrangement of the surface-binding pocket to produce good correlations between calculated and experimental binding energies.

Ann Marie Wellhouse, who founded a charter high school in the area, was visibly proud to see her students show people models of the HIV-1 protease and expertly explain the functional aspects of the structure.

Vimentin heads are able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis.

He is particularly noted for his early work on the HIV-1 protease, proteins involved in DNA repair such as uracil-DNA glycosylase and DNA-PKcs and the Hsp90 molecular chaperone system.

Protease inhibitors prevent viral replication by selectively binding to viral proteases (e.g. HIV-1 protease) and blocking proteolytic cleavage of protein precursors that are necessary for the production of infectious viral particles.

Lopinavir was marketed in 2000 and was originally designed to diminish the interactions of the inhibitor with Val82 of the HIV-1 protease, a residue that is often mutated in the drug resistant strains of the virus.

Johansson, H. Wallberg, M. Larhed, B. Samuelsson, T. Unge, A. Hallberg: Microwave accelerated synthesis of P'-extended HIV-1 protease inhibitors encompassing a tertiary alcohol in the transition-state mimicking scaffold.

A 1996 study by McPhee et al. suggested that stercobilin and other related pyrrolic pigments - including urobilin, biliverdin, dimethyl ester, and xanthobilirubic acid - has potential to function as a new class of HIV-1 protease inhibitors when delivered at low micromolar concentrations.