Fc receptors

Activation of phagocytes is the most common function attributed to Fc receptors.

Fc receptors bind to antibodies that are attached to infected cells or invading pathogens.

Fc receptors are also found on eosinophils, monocytes, macrophages and platelets in humans.

The antibodies bind to antibody Fc receptors that some of these cells have in their plasma membrane.

Phagocytes bind those Fc regions with their Fc receptors.

It expresses certain complement receptors as well as Fc receptors for immunoglobulin G.

Raji cells are a line EBV-transformed lymphocytes with surface Fc receptors.

Some viruses such as flaviviruses use Fc receptors to help them infect cells, by a mechanism known as antibody-dependent enhancement of infection.

Alternatively, donor cells are coated with alloantibodies that initiate phagocytosis through Fc receptors of mononuclear leukocytes.

The Fc receptors are isotype-specific, which gives greater flexibility to the immune system, invoking only the appropriate immune mechanisms for distinct pathogens.

During his studies there, Khayat worked on the identification and purification of the soluble Fc receptors both in mouse and human sera.

This category of organic molecules includes Fc receptors, Ulks, Calcineurins, K chips, and urocortins.

Another process involving Fc receptors is called antibody-dependent cell-mediated cytotoxicity (ADCC).

Note: IgG affinity to Fc receptors on phagocytic cells is specific to individual species from which the antibody comes as well as the class.

Use of F(ab')2 or Fab fragments ensures that the antibodies are binding to the antigen and not Fc receptors.

However, when these antibodies are immobilized (either by secondary antibody bound to plastic or by Fc receptors on other cells) considerable steric constraints emerge.

There are several different types of Fc receptors (abbreviated FcR), which are classified based on the type of antibody that they recognize.

Fc receptors on monocytes cause OKT-3 treated lymphocytes to internalize T3 and secrete IL-2.

The NK cell is then activated through the cross linking of the Fc receptors which sends a signal to induce apoptosis and cell death.

Antigens interact with IgE molecules already bound to high affinity Fc receptors on the surface of mast cells to induce degranulation.

Fc receptor-like molecules (FCRLs) are a class of proteins that resemble Fc receptors.

C5a also modulates the balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing the autoimmune response.

IgE primes the IgE-mediated allergic response by binding to Fc receptors found on the surface of mast cells and basophils.

Phagocytic cells express receptors, CR1 and Fc receptors, that bind opsonin molecules, C3b and antibody, respectively.

Since the Fc moiety is now unavailable to the Fc receptors of the reticuloendothelial cells, the normally occurring destruction of the platelets is prevented.