Baeyer-Villiger oxidation

The Baeyer-Villiger oxidation is another example of a biocatalytic reaction.

Key features of the Baeyer-Villiger oxidation are its stereospecificity and predictable regiochemistry.

Baeyer-Villiger oxidation may compete with dioxirane formation.

Caprolactone is prepared industrially by Baeyer-Villiger oxidation of cyclohexanone with peracetic acid.

Another important application is the synthesis of lactones of cyclic ketones in the Baeyer-Villiger oxidation process.

Many of them are capable of cleavaging electron-rich olefins and inducing Baeyer-Villiger oxidation.

Certain cyclic ketones are converted to the ring-expanded esters using peracids in a Baeyer-Villiger oxidation.

The reaction mechanism has similarities with the Baeyer-Villiger oxidation where the intermediate hydroxyperacid is called a Criegee intermediate.

The Baeyer-Villiger oxidation is an organic reaction in which a ketone is oxidized to an ester by treatment with peroxy acids or hydrogen peroxide.

The concerted mechanism of this step is similar to the mechanisms of the Baeyer-Villiger oxidation and also the oxidation step of hydroboration-oxidation.

The Baeyer-Villiger oxidation can also be performed by biocatalysis with a so-called Baeyer-Villiger monooxygenase or BVMO.

It is used as a reagent in the Baeyer-Villiger oxidation and in oxidation of carbon-carbon double bonds in alkenes to generate epoxides (oxiranes).

A Baeyer-Villiger oxidation converts the ketone to an ester (7) and a reduction with Raney nickel converts the ester into an alcohol and removes the triflic acid group.

The Dakin oxidation, which is closely related to the Baeyer-Villiger oxidation, is not to be confused with the Dakin-West reaction, though both are named after Henry Drysdale Dakin.

Some of his discoveries include the structure elucidation of the tropylium cation, the discovery of dichlorocarbene, bullvalene and fulvalene and the discovery of the mechanism of the Baeyer-Villiger oxidation.

The possibility that the entire molecule is assembled as a single polyketide with a Baeyer-Villiger oxidation inserting an oxygen into the carbon backbone has been ruled out because C1 of monic acid and C9' of 9-hydroxy-nonanoic acid are both derived from C1 of acetate.