ABC transporter

ABC transporters are also involved in multiple drug resistance, and this is how some of them were first identified.

The gene belongs to a family of genes known as ABC transporters.

This enzyme participates in abc transporters - general.

More than 100 ABC transporters are distributed from prokaryotes to humans.

For other types of drugs to work they must bypass the resistance mechanism, which is the ABC transporter.

The ABC transporters occur in all living organisms.

Several groups studying ABC transporters have differing assumptions on the driving force of transporter function.

Sav1866 is a homolog of multidrug ABC transporters.

Expression of ABC transporters in transfectant cells.

Bacterial ABC transporters are essential in cell viability, virulence, and pathogenicity.

Some ABC transporters have additional elements that contribute to the regulatory function of this class of proteins.

The physiologic function of ABC transporters is not well known, and they are expressed constitutively in more than just cancer cells.

It is reported that CED7 protein has sequence similarity to ABC transporters.

Modules frequently display different connectivity relationships, as illustrated by the kinesins and ABC transporters.

A large number of drugs are either transported by ABC transporters themselves or affect the transport of other drugs.

These drugs would not function as a substrate of ABC transporters, and would thus not be transported.

MDR is frequently associated with overexpression of ABC transporters.

The vesicular transport assay detects the translocation of molecules by ABC transporters.

ABC transporters are thought to participate in the absorption and secretion of endogenous and exogenous substances.

Species with this protein always lack the ThiBPQ ABC transporter.

ABC transporters are involved in the export or import of a wide variety of substrates ranging from small ions to macromolecules.

Although most eukaryotic ABC transporters are effluxers, some are not directly involved in transporting substrates.

ABC transporters are known to play a crucial role in the development of multidrug resistance (MDR).

Typical ABC transporter consists of two transmembrane domains and two nucleotide-binding domains.

When the ABC transporter proteins are overexpressed in cancer cells they can export anticancer drugs and render tumors resistant.