His success has had a profound impact on popular music.

Population growth has and will have a profound impact upon world food demand.

My experience with those kids had a profound impact on me.

Is this perhaps the result of a profound impact on human thought created by a book?

For all their differences, each man had a profound impact on the other's life and career.

I can't think of any other industry that has a more profound impact on people's lives.

This change has a profound impact on the way the game is played.

Recently, they have had a profound military impact on the area.

The disease can have a profound impact on quality of life.

Television's profound impact on board games is seen in just about every type of game.