transverse tubule

Ca1.1 is a voltage-dependent calcium channel found in the transverse tubule of muscles.

In skeletal muscle fibers a large transverse tubule system with a high surface-area to volume ratio exist.

Transverse tubules are invaginations of the sarcolemma.

Terminal cisternae are enlarged areas of the sarcoplasmic reticulum surrounding the transverse tubules.

In between two terminal cisternae is a tubular infoldings called a transverse tubule (T tubule).

This depolarizes the muscle fiber membrane, and the impulse travels to the muscle's sarcoplasmic reticulum via the transverse tubules.

Terminal cisternae is the enlargement of smooth endoplasmic reticulum found in muscle cells on either side of the transverse tubules.

The sarcolemma invaginates into the cytoplasm of the muscle cell, forming membranous tubules called transverse tubules (T-tubules).

A T-tubule (or transverse tubule) is a deep invagination of the sarcolemma, which is the plasma membrane, only found in skeletal and cardiac muscle cells.

The triad of transverse tubules surrounded by two smooth ER cisternae transmit altered membrane permeability down the tubules.

This depolarization spreads across the surface of the muscle fiber into transverse tubules, eliciting the release of calcium from the sarcoplasmic reticulum, thus initiating muscle contraction.

RYR1 functions as a calcium release channel in the sarcoplasmic reticulum, as well as a connection between the sarcoplasmic reticulum and the transverse tubule.

Interestingly, another AKAP governs voltage-dependent potentiation of L-type calcium channels through anchoring of PKA in transverse tubules [ 36 ] .

Rosemblatt M., Hidalgo C., Vergara C., Ikemoto N. Immunological and biochemical properties of transverse tubule membranes from rabbit skeletal muscle.

The onset of skeletal muscle activity is associated with the initiation and propagation of action potentials again associated with an efflux of K to the extracellular fluid and transverse tubule system.

These discrete regions within the muscle cell store calcium (increasing the capacity of the sarcoplasmic reticulum to release calcium) and release it when an action potential courses down the transverse tubules, eliciting muscle contraction.

Using confocal microscopy in conjunction with ANNINE-6plus, single sweep action potentials with high peak signal-to-noise ratio (SNR) have been recorded from single transverse tubule (t-tubule) of a few micrometers in the ventricular cardiomyocyte.