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At this stage, adjustments to the tablet weight are normally made by repositioning the lower punch.
However, a fast disintegration time and a small tablet weight can enhance absorption in the buccal area.
These devices use strain gauge technology at each compression station to monitor pressure, which is then calibrated to tablet weight.
Fluctuations in tablet weight, usually caused by uneven powder flow into the die due to poor powder flow properties.
Sometimes tablet weight and hardness will be determined at different stages during storage and also during the dissolution/release testing procedure.
Tablet presses must allow the operator to adjust the position of the lower and upper punches accurately, so that the tablet weight, thickness and density can each be controlled.
The high rate of tablet output of modern presses requires continuous tablet weight monitoring with electronic monitoring devices such as Thomas Tablet Sentinel, Pharmakontroll or Killan control System-MC.
From sampling of the raw materials on arrival to the finished product may involve over 20 QA tests and checking procedures per product, including micro-biological, HPLC, tablet weights, hardness, dissolvability and coatings etc.
