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These parent-of-origin effects reflect the effects of genomic imprinting.
Further simulations are needed to investigate whether the mechanisms underlying parent-of-origin effects can be distinguished in larger pedigree structures.
Detection of parent-of-origin effects for atopy by model-free and model-based linkage analyses.
This might indicate that parent-of-origin effects such as imprinting might be involved with the X chromosome skewing.
Finally, considerable focus has been placed on the environment, the finding of a strong maternal parent‐of‐origin effect appears to be critical for MS risk and this now 23
Skewing can also be influenced by the parent-of-origin effect, in which skewing becomes biased towards either the maternal or paternal X chromosome.
Imprinted Gene and Parent-of-origin Effect Database
The Catalogue of Imprinted Genes and Parent-of-origin Effects in Humans and Animals currently contains over 300 entries.
Furthermore, In Vargas' view, the parent-of-origin effect poorly understood at the time of Kammerer's work might be explained retrospectively, in relation to similar effects seen in other organisms.
Areas off the human genome linked with imprinted genes, psychosis, and parent-of-origin effects each occupy only a very small part of the human genome and overlap of these areas would not be expected if they were unrelated.
Gliboff goes on to strongly challenge Kammerer's being given credit for discovery of parent-of-origin effects, and to state that "Vargas' historical inferences about the Kammerer affair... [and] negative reactions of geneticists... are unsupported and do not stand up to scrutiny."
