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The nature of the space race has also changed profoundly since 1969.
"I think we have both been changed profoundly by this place, young friend."
This change profoundly affected the way the game was played.
They argue that America has changed profoundly and is now a very different country.
However, more recently, civil society organizations have expanded and changed profoundly.
We are heading to an era in which schooling will change profoundly.
Beginning in 1955, the year after his first museum show, Escher's work changed profoundly.
My attitude about cancer has changed profoundly since my return to America.
But each family's incentive to buy high-end toys would be changed profoundly.
Over these decades, both the composition and the reputation of products from Japan changed profoundly.
As the village becomes urbanized, cultural environment has changed profoundly.
The humanitarian context has changed profoundly in recent years.
Now, in the course of 20 years, the context of the negotiations has changed profoundly.
Yet the economy has changed profoundly since the earliest of those six recessions ended in 1961.
"That feeling has changed profoundly throughout the industrial world.
While society changed profoundly, political processes did not.
In the last three years, Hillary Clinton's public place in that relationship has changed profoundly.
In the course of this period, the situation in this region has changed profoundly.
Her life spanned a period in which customs, habits and morals had all changed profoundly.
With these differences eliminated, regional climates could be expected to change profoundly and disruptively.
Over this period the world changes profoundly.
Yet as he heard Marius say it, he changed profoundly, though none watching could guess in what way.
Their intentions are good, but they need to recognize that their kids have changed profoundly and will continue to do so."
Clausewitz may be able to provide a rationale for war today, but the nature of war itself has changed profoundly since he wrote.
The political landscape has also changed profoundly.