CpG island

CpG islands usually appear in the regulatory region at the beginning of a gene).

Recently a study showed that most CpG islands are a result of non-selective forces.

This gives the user a percentage methylation per CpG island.

Many genes have CpG islands, which frequently occur near the beginning of the gene.

This mechanism is important because it dictates the rarity of CpG islands.

Prostate cancer has been associated with gene silencing by CpG island hypermethylation.

There is much crosstalk between CpG island methylation and histone modifications.

However, objective definitions for CpG islands are limited.

Exon 1 is located within a strong CpG island, indicating the likely presence of a promoter in this region.

The genes for these two proteins are found in areas of the genetic code that can be methylated (see CpG island).

The methylation patterns of the E-cadherin 5' CpG island are not stable.

Modern epigenetics have correlated CpG island hypermethylation with unexpressed genes.

Transcription from methylated CpG islands is strongly and heritably repressed.

Hypermethylation typically occurs at CpG islands in the promoter region and is associated with gene inactivation.

Pioneer factors that bind to CpG islands and cysteine residues block access to methyltransferases.

In patients with breast cancer, hypermethylation of CpG islands located proximal to the transcription start site was observed.

Methylation of cytosines within a CpG island is a causative factor in gene silencing.

Many genes in mammalian genomes have CpG islands associated with the start of the gene (promoter regions).

Because of this, the presence of a CpG island is used to help in the prediction and annotation of genes.

CpG islands typically occur at or near the transcription start site of genes, particularly housekeeping genes, in vertebrates.

The percentage methylation of individual CpG islands can be determined by quantifying the amount of the target in each fraction.

We observed that 45% of the gene units were associated with CpG islands (defined as 10 kb upstream or within the gene).

This makes computational recognition of invertebrate promoters, and those vertebrate promoters not found in CpG islands, more difficult.

A base excision mediated demethylation mechanism would yield double strand breaks if it occurs on large scale in CpG islands.

There is a small fraction of CpG islands that can overlap or be in close proximity to promoter regions of transcription start sites.